Endocrine Abstracts

Section 1: Case history: A 37-year-old South Asian woman was referred to our diabetes clinic from the Diabetes Eye Screening Programme. Her retinal blood vessels appeared white, in contrast to the normal pink-red colour. The patient was diagnosed with diabetes secondary to chronic pancreatitis a year prior to this presentation, for which she was on metformin and long-acting insulin but had suboptimal control and multiple hospitalisations with chronic pancreatitis. She was prev...

Background: CAYA cancer survivors who received cranial radiotherapy have an increased risk of stroke. Traditional cardiovascular disease (CVD) risk factors likely contribute, but there are no guidelines for management of stroke risk in this population. It is unclear how general CVD risk calculators (QRISK3, Framingham Risk Score) compare to specific cancer survivors scores such as the Childhood Cancer Survivors Study Stroke Risk Calculator (CCSS).<p class=...

Background: Neuroendocrine malignancies are heterogeneous cancers with varied clinical outcomes. The molecular landscape driving this heterogeneity has not yet been fully characterized. We aimed to investigate the gene expression profiles of neuroendocrine neoplasms, in relationship to baseline clinicopathological features and clinical outcomes, to elucidate underlying biology and potential therapeutic targets.Methods: Patients with neuroendocrine tumors...

Background: Renal neuroendocrine tumors (NETs) are a particularly rare subset of NETs, with fewer than 100 cases described in the literature. Of these, next generation sequencing (NGS) findings have been described in fewer than 10 cases, all but one of which had grade 1 disease.Methods: A single-center, IRB-approved retrospective analysis of patients with grade 2 or 3 well-differentiated renal NETs treated at our institution from 2016-2023 for whom NGS d...

Background: As persistant organic pollutants, polychlorinated biphenyls (PCBs) are widespread in environment worldwide. Serum PCBs and nuclear factor erythroid 2-related factor 2 (NRF2) are associated with glucose homeostasis damage in the general population. However, there is a lack of epidemiological evidence on the interaction between serum PCBs and NRF2 gene in relation to glucose homeostasis damage.Objectives: We aimed to explore the intera...

Objective: Studies have demonstrated that patients with acromegaly have compromised bone health and an increased risk of vertebral fractures (VFs). However, the prevalence of VFs in Chinese patients with acromegaly has not been investigated by far. This study aimed to evaluate the prevalence and determinants of VFs in patients with acromegaly in a tertiary hospital in China.Methods: We enrolled patients diagnosed with acromegaly consecutively at West Chi...

Objective(s): Atypical femoral fractures (AFFs) are an important complication of treatment with anti-resorptive treatment, which remains the cornerstone of osteoporosis treatment. Recognition of this rare clinical entity is exceedingly important, as ongoing treatment with anti-resorptives is contraindicated. The American Bone and Mineral Research (ASBMR) have devised diagnostic criteria which are qualitative and subjective. Recent attempts have been made to create more quantit...

Objective: To investigate the prevalence of hyperuricemia in Chinese population, and the association between serum concentrations of uric acid and related metabolic disorders.Methods: This study was based on de-identified hospital information system (HIS) data collected from four tertiary hospitals in three provinces of China. A total of 432,002 patients with at least one medical visit recorded SUA measurement were screened and 374,506 were enrolled. Hyp...

Background and objective: Children with chronic kidney disease (CKD) have impaired growth that leads to short stature in adulthood and treatment with recombinant human growth hormone (rhGH) is associated with improved growth. This study aimed to evaluate the efficacy and safety of daily rhGH (Jintropin®) in children in China with growth failure caused by CKD prior to transplantation.Methods: Prepubertal patients (2–13 years old) with CKD-relate...

Introduction: As a tumor-suppressor gene, armadillo repeat-containing 5 (ARMC5) gene regulates steroidogenesis and cell apoptosis in manner of second-hit model. Mutations of ARMC5 gene will disturb its normal function, leading to reduced cortisol synthesis and cell apoptosis, which is acknowledged as a frequent cause of primary bilateral macronodular adrenal hyperplasia (PBMAH). Not until another somatic ARMC5 mutation occur in germline mutation carriers, will they manifest as...